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Over the years, its application has considerably expanded with accumulating evidence of beneficial effects in a broad range of conditions associated with CHRF. In Switzerland, long-term mechanical ventilation has been increasingly used since the 1980s in hospital and home care settings. It is aimed at improving CHRF-related symptoms, health-related quality of life, survival, and decreasing hospital admissions. Long-term mechanical ventilation is a well-established treatment for chronic hypercapnic respiratory failure (CHRF). SNIP, MIP, and VC all follow a relatively linear downhill course with a steeper slope for "bulbar" versus "non-bulbar" patients. There was no significant bias in favor of either test, but a considerable disparity in results between tests, suggesting that use of both tests is warranted to screen for early detection of patients at risk of respiratory failure and avoid over diagnoses. At different proposed cut-off values for identifying patients at risk of respiratory failure, the agreement between MIP and SNIP (64-79%) and kappa values (0.29-0.53) was moderate. Results were similar in "bulbar" versus "non-bulbar" patients. Correlation between MIP and SNIP (Pearson's rho: 0.68, p < 0.001) was moderate, with a non-significant bias in favor of SNIP (3.6 cm H2O) and wide limits of agreement (-34 to 41 cm H2O). SNIP and MIP could not be performed in 14 (21%) subjects 74% of the subjects showed a decrease in MIP or SNIP at inclusion versus 31% for VC. Pulmonary follow-up included forced expiratory volumes, vital capacity (VC) seated and supine, MIP, SNIP, pulse oximetry, and daytime arterial blood gases.Ī total of 61 patients were included. Patients with MND followed by a multidisciplinary consultation were prospectively included. The aim of this study was to compare the feasibility, agreement, and performance of both tests in MND. Regular assessment of sniff nasal inspiratory pressure (SNIP) and/or maximal mouth inspiratory pressure (MIP) contributes to early detection of a requirement for ventilatory support. Motor neuron disease (MND) invariably impacts on inspiratory muscle strength leading to respiratory failure.